This past week we received our official notice of award for our R01 submission to the NIH/NIDDK! The lab is excited to study 'The role of NCOA4-mediated ferritinophagy in iron homeostasis and ferroptosis.' From our project summary:
Specific Aim 1 will define the biochemical mechanisms regulating NCOA4 activity in cells using an integrated quantitative proteomic and cell biologic experimentation workflow. In specific aim 2, we will determine the temporal and spatial dependency of ferritinophagy in vivo for regulating systemic iron homeostasis and erythropoiesis using novel mouse models of NCOA4 knockout and over-expression. Finally, specific aim 3 will focus on examining a role for NCOA4 in regulating sensitivity to ferroptosis in vivo under pathophysiologic conditions, including pancreatic cancer. Together, the proposed in vitro and in vivo studies will identify fundamental roles of NCOA4 in sensing and responding to iron deficiency and overload and determine the utility of pursuing NCOA4 as a therapeutic target for multiple iron-related disorders.
A funded postdoctoral fellow position is available in our lab. This is a great opportunity to study pancreatic cancer biology in our group. We have ongoing projects in: selective autophagy, therapeutic resistance, and radiation-induced immune responses. Please see the link for the full job description: https://careers-dfci.icims.com/jobs/18785/research-fellow/job?mode=view&mobile=false&width=783&height=500&bga=true&needsRedirect=false&jan1offset=-300&jun1offset=-240
Our first bioRxiv pre-print: Defining and targeting adaptations to oncogenic KRASG12C inhibition using quantitative temporal proteomics
Naiara Santana-Codina presents a poster at the 2019 AACR Pancreatic Cancer: Advances in Science and Clinical Care
Collaboration with Sahar Nissim and Goessling Lab published in Nature Genetics: Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer