New paper from the lab published in Cancer Discovery!

Our latest publication is now online at Cancer Discovery! Here, we demonstrate that "NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins."  To study the role of NCOA4 in PDAC, we used orthogonal approaches including bioinformatics of large-scale loss-of- function genetic screens, autochthonous tumor models, cell lines, and human tumor genetics. Naiara Santana-Codina led the work with significant contributions from many others in the lab as well as collaborations from the Nowak Lab and the Aguirre Lab at DFCI , and Yatrik Shah's lab at University of Michigan. Check out the study at this link:
​https://aacrjournals.org/cancerdiscovery/article/doi/10.1158/2159-8290.CD-22-0043/704854/NCOA4-mediated-ferritinophagy-is-a-pancreatic