Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Mancias and colleagues develop a method for quantitative proteomic analysis of purified autophagosomes and identify NCOA4 as a selective cargo receptor for autophagic turnover of ferritin (ferritinophagy), which is critical for iron homeostasis. The work also provides a resource for further dissection of autophagosomal cargo–receptor connectivity. This work was completed during Joe's post-doctoral fellowship in the labs of Alec Kimmelman and Wade Harper and was published in Nature. |
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