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Mancias Lab - Pancreatic Cancer Research

Mancias Laboratory
PANCREATIC CANCER RESEARCH

Joe presents at the NCI GI-Pancreas SPORE Workshop hosted at the University of Nebraska Medical Center

10/29/2018

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As part of the team representing the GI SPORE at Dana-Farber/Harvard Cancer Center, Joe presents his work on therapeutic resistance to pre-clinical targeted therapy in Pancreatic Cancer models, including published work on glutaminase inhibitors and unpublished work (supported by a Career Enhancement Program Award from the DF/HCC GI SPORE) on pharmacologic oncogenic KRAS inhibitors. Check out the agenda of the meeting here: GI SPORE Workshop Agenda. Fantastic hosts at the UNMC show us their amazing Chihuly Sanctuary, pictures below!
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Lab publishes a review on: The Role of NCOA4-Mediated Ferritinophagy in Health and Disease.

10/23/2018

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Naiara Santana-Codina publishes an invited review in a special issue of Pharmaceuticals on the role of iron metabolism in health and disease. Her review focused on the growing body of evidence from the Mancias Lab and others linking NCOA4, the selective autophagy receptor for ferritin, with important physiologic processes such as erythropoiesis and with pathophysiology including iron deficiency anemia, ferroptosis (an iron-dependent form of cell death), neurodegeneration, and potentially cancer. Check out the open access article here: ​The Role of NCOA4-Mediated Ferritinophagy in Health and Disease.
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