In collaboration with the Gujar Lab, the Mancias Lab developed an innovative multiplexed quantitative mass spectrometry-based approach towards identifying MHC-I ligands that will be instrumental in our project identifying the MHC-I ligands that change in response to radiation therapy. Here is a link to the journal website, feel free to contact the lab for a pdf of the paper.
The Mancias Lab publishes a collaborative paper with the Gujar Lab in Analytical Chemistry: Multiplexed Relative Quantitation with Isobaric Tagging Mass Spectrometry Reveals Class I Major Histocompatibility Complex Ligand Dynamics in Response to Doxorub
Schematic of the MHC-I ligandome workflow.
Joe visits MD Anderson Cancer Center to present his work on therapeutic resistance and the interaction between radiation therapy and immunotherapy
Joe presents at the DF/HCC: Topics in Gastrointestinal Cancer CME Course on the role of Radiation Therapy in Pancreatic Cancer
Lab publishes a paper in Haematologica: NCOA4 Maintains Murine Erythropoiesis Via Cell Autonomous And Non-Autonomous Mechanisms
Joe presents at the NCI GI-Pancreas SPORE Workshop hosted at the University of Nebraska Medical Center
As part of the team representing the GI SPORE at Dana-Farber/Harvard Cancer Center, Joe presents his work on therapeutic resistance to pre-clinical targeted therapy in Pancreatic Cancer models, including published work on glutaminase inhibitors and unpublished work (supported by a Career Enhancement Program Award from the DF/HCC GI SPORE) on pharmacologic oncogenic KRAS inhibitors. Check out the agenda of the meeting here: GI SPORE Workshop Agenda. Fantastic hosts at the UNMC show us their amazing Chihuly Sanctuary, pictures below!